|
Symbol Name ID |
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2) MGI:95821 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Spasticity |
Gliosis |
Cerebellar atrophy |
Neuronal loss in central nervous system |
Gait ataxia |
Bradykinesia |
Chorea |
Myoclonus |
EEG abnormality |
Hypsarrhythmia |
Reduced eye contact |
Absent speech |
Depression |
Delusion |
Schizophrenia |
Hallucinations |
Atypical behavior |
Negativism |
Personality changes |
Dementia |
Social and occupational deterioration |
Intellectual disability |
Hyperreflexia |
Dyskinesia |
Dystonia |
Epileptic encephalopathy |
Global developmental delay |
Delayed ability to sit |
Seizure |
Bilateral tonic-clonic seizure |
Focal impaired awareness seizure |
Epileptic spasm |
Infantile spasms |
Myoclonic seizure |
Status epilepticus |
| Disease(s) Associated with GRIN2B | ||||||||||||||||||||||||||||||||||||
| autosomal dominant intellectual developmental disorder 6 | ||||||||||||||||||||||||||||||||||||
| developmental and epileptic encephalopathy 27 | ||||||||||||||||||||||||||||||||||||
| Huntington's disease | ||||||||||||||||||||||||||||||||||||
| schizophrenia |
| Mouse Phenotypes | nervous system phenotype |
disorganized barrel cortex |
abnormal dendrite morphology |
decreased dendritic spine density |
increased dendritic spine density |
abnormal synapse morphology |
abnormal nervous system physiology |
impaired synaptic plasticity |
abnormal CNS synaptic transmission |
abnormal excitatory postsynaptic currents |
decreased excitatory postsynaptic current amplitude |
short excitatory postsynaptic current decay time |
abnormal excitatory postsynaptic potential |
abnormal AMPA-mediated synaptic currents |
abnormal NMDA-mediated synaptic currents |
absence of NMDA-mediated synaptic currents |
reduced long-term potentiation |
abnormal miniature excitatory postsynaptic currents |
increased prepulse inhibition |
abnormal long-term depression |
absent long-term depression |
reduced long-term depression |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||
| Grin2bem1Weya/Grin2bem1Weya | * | ||||||||||||||||||||||
| Grin2btm1.1Jwhe/Grin2btm1.1Jwhe | * | ||||||||||||||||||||||
| Grin2btm1Mim/Grin2btm1Mim | |||||||||||||||||||||||
| Grin2btm1Rsp/Grin2btm1Rsp | |||||||||||||||||||||||
| Grin2btm1Tya/Grin2btm1Tya | * | ||||||||||||||||||||||
| Grin2btm2Mim/Grin2btm2Mim | |||||||||||||||||||||||
| Grin2btm1Mim/Grin2b+ | |||||||||||||||||||||||
| Grin2btm1Rsp/Grin2b+ | |||||||||||||||||||||||
| Grin2btm1.1Jlbr/Grin2btm1.1Jlbr Tg(Camk2a-cre)T29-1Stl/0 (conditional) |
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| Grin2btm1Ksak/Grin2btm1Ksak Grik4tm1(cre)Ksak/Grik4+ (conditional) |
* | ||||||||||||||||||||||
| Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc/0 (conditional) |
* | ||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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